The City of DeQuincy was established in 1897 when the Kansas City, Pittsburgh, and Gulf Railway, now the Kansas City Southern, reached the point where its main line bent toward the southwest to Beaumont and the old Calcasieu River. Vernon & Shreveport tram line, now the Lake Charles branch of the K.C.S., joined the main line, and the town of DeQuincy was formed. DeQuincy was at this time a pine forest, no timber having been cut except on the railroad right-of-way. Two small stores, two boarding houses, and four small dwellings constituted the village.
DeQuincy has seen tremendous growth since those pioneering days and is now a thriving city hosting one of the most unique museums in Louisiana, the DeQuincy Railroad Museum. Home to the DeQuincy High School Fighting Tigers, numerous delicious restaurants, and a variety of community events, DeQuincy's busiest time of year is during the Louisiana Railroad Days Festival, held annually on the second weekend of April.